A mitochondrial uncoupler studied in metabolic research
Metabolic researchEvidence: preclinicalRUO · not approved
Research Use Only. Not an approved medicine and not for human use. Educational only — no dosing or medical advice.
What it is
BAM-15 is a small-molecule mitochondrial uncoupler (not a peptide) studied as a potentially safer successor to older uncouplers like DNP.
Proposed mechanism
Uncouplers dissipate the mitochondrial proton gradient so cells burn more fuel as heat rather than making ATP, increasing energy expenditure in animal models.1 Uncoupling has a narrow safety margin historically.
State of the evidence
Preclinical; no human efficacy/safety trials establishing use.
Regulatory & status
Not approved; RUO.
References
Mitochondrial uncouplers in metabolism (literature). PubMed: BAM-15
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